A new study from our lab was published today in Stem Cell Research titled "Lgr5-positive endothelial progenitor cells occupy a tumor and injury prone niche in the kidney vasa recta". This was a collaborative study with many contributors from the Van Andel Research Institute and Mayo Clinic. The paper can be found here.
The lab's latest publication was released today in the journal Epigenetics & Chromatin. This methodology article, titled "ATAC-seq normalization method can significantly affect differential accessibility analysis and interpretation," was spearheaded by graduate student Jake Reske and provides important evidence helping to improve data interpretation of a cutting edge technique used to measure chromatin accessibility (i.e. DNA packaging within a cell).
This week our lab has published a new paper in Human Reproduction titled "A Mouse Model of Endometriosis Mimicking the Natural Spread of Invasive Endometrium" (PMID: 31886851),
The MSU Institute for Cyber-Enabled Research (ICER) operates and manages the high-performance computing cluster services used by computational researchers across many fields at MSU. In this month's Student Highlights section, ICER highlighted Chandler Lab's graduate student Jake Reske and his computational biomedical research, which involves a lot of data. Read more in the ICER Student Highlights article, "Applying Genomics to Develop an Understanding of Uterine Cancer". Thanks, ICER!
On Friday, Chandler lab postdoctoral fellow Mike R Wilson was presented with the Outstanding Researcher Award from the American Cancer Society's Associate Board of Ambassadors for his work in the fields of endometrial cancer and endometriosis-associated ovarian cancer. The award was presented at the Young Professionals Finding a Cure Gala "A Night in Havana" in downtown Grand Rapids. Congrats, Mike!
Nina Cuthrell is a pre-medicine student at Hope College. She has done a few semesters of psychology research at Hope College, but was intrigued by Dr. Chandler’s endometriosis research and decided to reach out to him. After being diagnosed with endometriosis at the age of 14, studying gynecological diseases became Nina's life project. She aims to become a pediatric gynecologist to help young women who are going through what she went through. When not in classes or research, you can find Nina playing with her dog, watching movies, or drinking coffee with friends.
Yesterday, September 26th, marked the annual MSU Reproductive and Developmental Sciences Program (RDSP) Research Day, which was held in Portland, MI. This yearly event showcases the latest research from MSU scientists focusing on reproductive and developmental biology. Chandler lab graduate student Jake Reske was selected to give an oral presentation on his research, titled "Genome-wide analysis of chromatin structure and function following ARID1A loss in endometriosis." Jake received the Best Oral Presentation Award for his talk at this meeting. Great work, Jake!
Our work has been chosen to be featured among a select group of ACS funded ovarian cancer studies. Mike's fellowship project, "Defining the role of endometrium in endometriosis-associated ovarian cancer," will contribute to our understanding of ovarian cancer progression. You can find the Ovarian Cancer Research Highlights here.
Dr. Chandler was interviewed by "The Scientist" about our recently published study. You can read that article titled "Two Genes Conspire in Endometriosis and Cancer to Help Cells Migrate" here.
The Chandler Lab is pleased to announce the publication of it's most recent paper. The paper titled "ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion" was published in the journal Nature Communications on August 7, 2019. Click the link to access the paper.
To read more about the paper, including an interview with Dr. Chandler from MSU Today, click on this link.