Image: Ovarian Surface Epithelial Cells at 48 hours (in vitro)
Our current research focuses on the ARID1A gene (a subunit that facilitates SWI/SNF nucleosomal target substrate recognition), and it's interaction with other genes in the female reproductive system. ARID1A in it’s mutated form, has been associated with endometriosis-associated cancers of the female reproductive tract, as well as gastric and pancreatic cancers.
Other genes of interest include: PIK3CA (a PI3-kinase), BAF180 (an alternative SWI/SNF subunit), TRP53 (a tumor suppressor), ARID2 (an alternative SWI/SNF subunit), and PTEN (a gene which helps to prevent uncontrolled cell growth that can lead to tumors).
In-vitro projects include preclinical drug studies and chromatin-based mechanisms of ovarian tumor suppression.
In-vivo, genetically-modified mouse models (GEMM) model tumor growth and metastasis.