Image: Ovarian Surface Epithelial Cells at 48 hours (in vitro)
Our current research focuses on the ARID1A (a subunit that facilitates SWI/SNF nucleosomal target substrate recognition), and it's interaction with other proteins and signaling pathways in the female reproductive system. ARID1A is mutated in endometriosis and endometriosis-associated cancers of the female reproductive tract, as well as breast, gastric, bladder and pancreatic cancers.
Other genes of interest include: PIK3CA (a PI3-kinase), CHD4 (a SWI/SNF-like remodeler) BAF180 (an alternative SWI/SNF subunit), TRP53 (a tumor suppressor), ARID1B and ARID2 (alternative SWI/SNF ARID subunits), and PTEN (a gene which helps to prevent uncontrolled cell growth that can lead to tumors).
In-vitro projects include preclinical drug studies and chromatin-based mechanisms of disease prevention.
In-vivo, genetically-modified mouse models (GEMM) model of gynecologic disease and cancers.
Genomic studies to explore genome-wide SWI/SNF function in the female reproductive tract.
Biochemical studies of ARID subunit interaction partners and nucleosomal binding substrates.