Chandler lab graduate student Jake Reske successfully defended his doctoral dissertation in fulfillment of the MSU Genetics and Genome Sciences program, titled, "ARID1A mutant pathogenesis of the endometrial epithelium." Congratulations, Dr. Reske!

This Fall semester, two Michigan State University BioMolecular Science graduate students will be rotating in the Chandler lab: Hilary Skalski and Georgina Brown. We look forward to their time in the lab. Welcome!

After a successful Summer rotation, Shannon Harkins, MS, has joined the Chandler lab as a Michigan State University graduate student toward her PhD dissertation in the Genetics and Genome Sciences Program. Welcome, Shannon!

This week we are joined by a new MSU graduate student in the lab, Shannon Harkins, for a summer rotation, Welcome, Shannon!

The Michigan State University College of Human Medicine has recognized Ronald Chandler with the Early Career Research Excellence Award! Well done, Ron! Click here to see all of the 2020 Faculty Awards.

Our study of the role of ARID1A in preventing hyperacetylation of super-enhancers is out today in Cell Reports. Mike Wilson and Jake Reske are co-first authors of the study, and with additional contributions from Chandler Lab members Jeanne Holladay, Subechhya Neupane, Nina Cuthrell and Julie Ngo. This study was performed in collaboration with groups from University of British Columbia, Wake Forest and the Van Andel Research Institute. Check out the paper here.

This week our lab will attend the first AACR Endometrial Cancer conference. Dr. Chandler will present a talk titled "Chromatin regulation of the endometrium: What are our models telling us?" as a part of Plenary Session 6: Novel Model Systems. Mike Wilson will present a virtual poster titled "Inhibition of P300 histone acetyltransferase activity rescues invasive phenotypes of ARID1A-deficient endometrial epithelium" in the Targeted Therapeutics group. Jake Reske will present a virtual poster titled "ARID1A prevents H3K27-hyperacetylation at active super-enhancers" in the Functional Genomics and Proteomics group.

Our latest study, titled "SWI/SNF inactivation in the endometrial epithelium leads to loss of epithelial integrity," has been released today in Human Molecular Genetics. Jake Reske and Mike Wilson are co-first authors of this study, which was completed in collaboration with the Van Andel Research Institute Genomics Core.